PERSPECTIVES OF THE USE OF SULFORAPHANE IN ANIMAL MODEL OF COLORECTAL CARCINOGENESIS IN BRAZIL A REVIEW

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César Augusto Sobrinho
Evair Moisés de Lima Santiago
Marcelo Barbosa Neves
Alessandra de Figueiredo Gonçalves
Eliza Miranda Ramos
Ricardo Dutra Aydos
Rondon Ramalho

Abstract

Colon cancer is a growing health problem in Brazil. According to data from the World Health Organization (WHO), colon cancer is among the top ten causes of mortality and morbidity in the world. Besides, the disease has a significant economic impact on the Brazilian public health system. Over the past five years, there has been an increased interest in use, isolation, characterization and determination of the biological actions of compounds such as broccoli. Experimental studies with genetically modified (GMOs) rats, mice, and rats using Sulforaphane have demonstrated their ability to prevent, delay and reverse pre-neoplastic lesions, improved survival, as well as acting on neoplastic cells with therapeutic action. Sulforaphane through activation of Nrf2 increases the activity of phase II enzymes such as glutathione S transferase (GST), which is involved in the elimination of xenobiotic compounds. Aberrant crypts are induced, in Wistar rats and mice, by genotoxic and non-genotoxic chemical compounds. Colon carcinogenesis is generally induced in rats and mice by two substances, 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM). Azoxymethane is often used concerning DMH because it is more potent and requires few reactions for its activation. It is possible to conclude that Sulforaphane, through its various biological actions, presents efficiency in the prevention of colon cancer and significant potential for use in future experimental studies with genetically modified rats, mice, and rats.

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Augusto Sobrinho, C., de Lima Santiago, E. M., Barbosa Neves, M., de Figueiredo Gonçalves, A. ., Miranda Ramos, E. ., Dutra Aydos, R. ., & Ramalho, R. (2019). PERSPECTIVES OF THE USE OF SULFORAPHANE IN ANIMAL MODEL OF COLORECTAL CARCINOGENESIS IN BRAZIL: A REVIEW. International Journal for Innovation Education and Research, 7(12), 421-427. https://doi.org/10.31686/ijier.vol7.iss12.2088
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Articles
Author Biographies

César Augusto Sobrinho, Fellow Master degree, Postgraduate Program in Health and Development in the Midwest Region,

UFMS, Campo Grande-MS, Brazil

Evair Moisés de Lima Santiago, Fellow medical undergraduate, Faculty of Medicine,

UFMS, Campo Grande-MS, Brazil

Marcelo Barbosa Neves, Fellow Master degree, Postgraduate Program in Health and Development in the Midwest Region,

UFMS, Campo Grande-MS, Brazil

Alessandra de Figueiredo Gonçalves, Fellow Master degree, Postgraduate Program in Health and Development in the Midwest Region,

UFMS, Campo Grande-MS, Brazil

Eliza Miranda Ramos, Fellow Master degree, Postgraduate Program in Health and Development in the Midwest Region,

UFMS, Campo Grande-MS, Brazil

Ricardo Dutra Aydos, Full Professor, Postgraduate Program in Health and Development in the Midwest Region,

UFMS, Campo Grande-MS, Brazil

Rondon Ramalho, Full Professor, Postgraduate Program in Health and Development in the Midwest Region,

UFMS, Campo Grande-MS, Brazil

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