Synthesis and Antibacterial Property of An Encapsulated Sulfonamide Nanoparticle in a Multidisciplinary Approach
Keywords:Nanoparticle, Multidisciplinary, Dendrimer, Antibiotic, Sulfonamide
Multigram quantity of a novel Sulfa Drug complex -poly(amido)amine-sulfonamide or PAMAM-Sulfa- was synthesized, from commercially available materials. It was characterized with spectroscopic methods such as nuclear magnetic resonance (NMR). The Kirby-Bauer test was used to test it against gram positive and/or gram negative bacteria using different concentrations of an ethanol solution of the PAMAM-Sulfa complex. The goal of this experiment was to synthesize and study the effect of water soluble encapsulated sulfonamides on common bacteria by undergraduate students engaging in research involving more than one STEM discipline. Students synthesized a dendrimer-sulfonamide complex before evaluating its antibiotic properties. In doing so, students employed research methods that are common to chemistry, biology and nanoscience while also learning about mechanism of infectious diseases, drugs and drug resistance. This project allowed students to combine aspects of scientific research that are usually done separately, and an opportunity to observe the seamlessness of multidisciplinary science.
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Copyright (c) 2021 Ashli Brown, Mercedes Fernandez, Shaquan Parker, ZeAndra D. Whitfield, Xiaomei Zheng , Ghislain R Mandouma
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