• Emílio Daniel Pacheco de Sousa Universidade Federal do Amapá
  • Givago da Silva Souza Universidade Federal do Pará https://orcid.org/0000-0002-4525-3971
  • Nely Deyse Santos da Mata Universidade Federal do Amapá https://orcid.org/0000-0002-0245-8141
  • Marlucilena Pinheiro da Silva Universidade Federal do Amapá
  • José Mauro Secco Universidade Federal do Amapá




Cancer, Mama, Risk factors, Malignant Breast Neoplasm


Breast cancer is a disease of epidemiological concern worldwide, being considered a serious public health problem. Although it is well established that early diagnosis and adequate treatment interfere with mortality rates and the prevalence of cancer, few data are available regarding the descriptive epidemiology of breast cancer in Brazil, as well as in the various states of the federation, as is the State of Amapá. The general objective was to characterize the risk factors of breast cancer patients treated at Hospital de Clínicas Dr. Alberto Lima (HCAL) from January 2012 to December 2017 in the city of Macapá, Amapá. Cases of breast cancer were reviewed, with an analysis of 194 medical records, and the following variables were studied: age, education level, histological type of the neoplasia, age at first delivery, menarche and menopause, breastfeeding time, alcohol intake, smoking, family history of breast cancer in first-degree relatives. It was noted that the age group most affected was between 41-50 years old and with an education level of elementary education. In these women, the most frequent characteristics were: age at first delivery between 13-20 years, menarche between 10-13 years, menopause from 41-50 years with a significant number of patients at menace (outside menopause), breastfeeding time between 2-22 and 23-42 months, both intervals with the same number of records; most did not drink alcohol, were not smokers and had no family history of first-degree relatives of breast cancer. In the cases studied, the most frequently diagnosed histological type was invasive ductal carcinoma.


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Author Biographies

Emílio Daniel Pacheco de Sousa, Universidade Federal do Amapá



Givago da Silva Souza, Universidade Federal do Pará


Nely Deyse Santos da Mata, Universidade Federal do Amapá


Marlucilena Pinheiro da Silva, Universidade Federal do Amapá


José Mauro Secco, Universidade Federal do Amapá



AMERICAN CANCER SOCIETY. Cancer Statistics Center. Atlanta, 2018. Available at. Accessed on: 22 jun. 2018.

AMERICAN COLLEGE OF RADIOLOGY. Breast Imaging Reporting Data System (BI-RADS®). 5. ed. Reston, VA: American College of Radiology, 2014.

COLDMAN, A. et al. Pan-Canadian study of mammography screening and mortality from breast cancer. Journal of the National Cancer Institute, v. 106, n. 11, 2014.

BARBOSA, R.S.; FERREIRA, R.K.R.; FAUSTINO, R.S.; SILVEIRA JUNIOR, L.S. Breast Cancer in Rio Grande do Norte, a retrospective study: Epidemiological, Clinical and Therapeutic Profile. NATAL, RN. Mastology. 2017; 27 (2): 109-16. DOI: https://doi.org/10.5327/Z2594539420170000174

BODMER, A. et al. Breast cancer in younger women in Switzerland 1996-2009: A longitudinal population-based study. Breast, v. 24, n. 2, p. 112-117, 2015. DOI: https://doi.org/10.1016/j.breast.2014.11.004

BRAZIL. Ministry of Health. Secretariat of Science, Technology and Strategic Inputs. National Commission for the Incorporation of Technologies in SUS (CONITEC). Trastuzumab for the treatment of metastatic HER 2- positive breast cancer in the first line of treatment. Recommendation Report. Brasília: Ministry of Health, 2017.

COLDMAN, A. et al. Pan-Canadian study of mammography screening and mortality from breast cancer. Journal of the National Cancer Institute, v. 106, n. 11, 2014. DOI: https://doi.org/10.1093/jnci/dju261

COLLINS, L.C. et al. Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer. Breast Cancer Research and Treatment, v. 131, p. 1061–1066, 2012. DOI: https://doi.org/10.1007/s10549-011-1872-9

COLLINS, L.C. et al. BI-RADS® classification. In: URBAN, L. Breast diseases: evidence-based pocket guide. São Paulo: Atheneu, 2013. cap. 1, p. 2.

COLLINS, L.C. et al. Staging and prognostic factors. In: LUZZATO, F. Breast diseases: evidence-based pocket guide. São Paulo: Atheneu, 2013. cap. 27, p. 222.

CHAGAS, C.R. Population aspects of breast cancer. Rev. Bras. Mastology. 1994; 3 (4): 11-6.

FARINA, A. et al. Epidemiological, clinical, anatomopathological and immunohistochemical profile of patients with breast cancer in Cuiabá (MT). See. Bras. Mastology. 2017; 2 (1): 74-9.

FRASSON, A. and Cols. Breast diseases: evidence-based pocket guide. 1st ed. São Paulo: Atheneu, 2013. P. 61-68.

FRASSON, A. et al. Histopathological classification of invasive carcinomas. In.: BACCHI, C. Breast diseases: evidence-based pocket guide. São Paulo: Atheneu, 2013. cap. 26, p. 206-213.

FREITAS-JUNIOR, R. et al. Disparities in female breast cancer mortality rates in Brazil between 1980 and 2009. Clinics (São Paulo), v. 67, p. 731–7, 2012. DOI: https://doi.org/10.6061/clinics/2012(07)05

GARICOCHEA, B. et al. Age as a prognostic factor in early stage breast cancer. Revista Saúde Pública, vol. 43, n. 2, p. 311-317, 2013. DOI: https://doi.org/10.1590/S0034-89102009005000009

GOKSU, S. S. et al. Clinicopathologic features and molecular subtypes of breast cancer in young women (age ≤ 35). Asian Pacific Journal of Cancer Prevention, v. 15, p. 6665–6668, 2014. DOI: https://doi.org/10.7314/APJCP.2014.15.16.6665

GONÇALVES, L.C.C. et al. Female breast cancer: Clinical and pathological aspects of cases registered from 2005 to 2008 in a public oncology service in Sergipe. ARACAJU (SE). Rev. Bras. Health Mater. Infant. 2012; 12 (1): 47-54.

HARBEK, N.; GNANT, M.; THOMSSEN, C. St. Gallen 2013: Brief Preliminary Summary of the Consensus Discussion. Breast Care, v. 8, p. 102–109, 2013. DOI: https://doi.org/10.1159/000351193

INUMARU, L. E; SILVEIRA, A; NAVES, M. M. Risk and protective factors for breast cancer: a systematic review. Public Health Notebooks, v. 27, n. 7, p. 1259-1270, 2011. DOI: https://doi.org/10.1590/S0102-311X2011000700002

JONES, J. A. et al. Dietary energy density is positively associated with breast density among young women. Journal of the Academy of Nutrition and Dietetics, v. 115, n. 3, p. 353-359, 2015. DOI: https://doi.org/10.1016/j.jand.2014.08.015

KALLEL, M. et al. Breast cancer in young women in southern Tunisia: Anatomical study and clinical prognostic factors: About a series of 83 patients. Reports of Practical Oncology and Radiotherapy, v. 20, p. 155–160, 2015. DOI: https://doi.org/10.1016/j.rpor.2015.01.007

LAUTER, D.S. et. al. Clinical and epidemiological profile of cancer patients. CONVIBRA, 2014. Available at: Accessed on: 28 mai. 2019.

LEITE, F.M.C. et al. Women diagnosed with breast cancer undergoing tamoxifen treatment: sociodemographic and clinical profile. Rev. Bras. Cancerology. 2011; 57 (1): 15-21.

LEME, L.H.S. Epidemiological, Clinical and Therapeutic Aspects of Breast Cancer in Men. Dissertation (Master's Degree in Tocogynecology) - Graduate Program of the Faculty of Medical Sciences, State University of Campinas, Campinas. 2005.

LIMA, G.R.; QUADROS, L.G.A. Breast cancer: epidemiology, risk factors and prevention attempts. GO Current 1992; 1 (2): 77-80.

MAHMOOD, U. et al. Similar survival with breast conservation therapy or mastectomy in the management of young women with early-stage breast cancer. International Journal of Radiation Oncology Biology Physics, 2012. DOI: https://doi.org/10.1016/j.ijrobp.2011.10.075

MARTINS, A. C. et al. Evolution of breast cancer mortality in young women: challenges for an oncology care policy. Brazilian Journal of Cancerology, v. 59, n. 30, p. 341-349, 2013.

MCPHERSON, K.; STEEI, C. M.; Dixon, J.M. ABC of Breast Diseases Breast câncer — epidemiology, risk factors and genetics. British Medical Journal, v. 321, p. 624-628, 2000. DOI: https://doi.org/10.1136/bmj.321.7261.624

MENKE, C.A.; BIAZÚS, J.V.; CAVALHEIRO J.A.; RABIN, E.G.; CERICATTO, R.; BITTELBRUNN, A.C.; XAVIER, N.L. Malignant breast pathology. In: FREITAS, F.; MENKE, C.H.; RIVOIRE, W.; PASSOS, E.P. Routines in Gynecology. 4th ed. Porto Alegre: Artmed, 2015. p. 340-56.

MENKE, C.A.; BIAZÚS, J.V.; CAVALHEIRO, J.A, RABIN, E.G.; CERICATTO, R., BITTELBRUNN, A.C.; XAVIER, N.L. Mastology routines. 4th ed. Porto Alegre: Artmed, 2016. p.119- 42.

METCALFEE, K. et al. Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. British Journal of Cancer, v. 104, n. 9, p. 1384–1392, 2011. DOI: https://doi.org/10.1038/bjc.2011.120

MILLES, R.C. et al. Local recurrence after breast-conserving surgery: multivariable analysis of risk factors and the impact of young age. Annals of Surgical Oncology, v. 19, p. 1153–1159, 2012. DOI: https://doi.org/10.1245/s10434-011-2084-6

MINISTRY OF HEALTH; National Cancer Institute José Alencar Gomes da Silva (INCA). The situation of breast cancer in Brazil: synthesis of data from information systems. 1st ed. Rio de Janeiro: INCA, 2019.

MOURA, L.N.M.; SILVA, B.B. Clinical and Epidemiological Profile Study of Patients with Breast Cancer seen at a public reference hospital in Terezina-PI, 2015. Available at: . Accessed on: 28 mai. 2019.

NAZÁRIO, A.C.P. Mastology: current conduct. 1st ed. São Paulo: 2016. p. 78-92.

PEREIRA, H.F.B.E.S.A. Epidemiological and Clinical Profile of young women with breast cancer in Amazonas: 11-year study. Dissertation (Master in Health Sciences) - Postgraduate Program in Health Sciences, Federal University of Amazonas, Manaus. 2016.

PIMENTEL, V.N.; SILVA, L.M.V.; PAIM, J.S.; COSTA, M.C.N. Evolution of breast cancer mortality. Salvador (BA) 1979-1996. Rev. Bras. Cancerology. 2002; 48 (4) 505-9. DOI: https://doi.org/10.32635/2176-9745.RBC.2002v48n4.2155

PINOTTI, J.A.; TEIXEIRA, L.C. Breast cancer: importance, epidemiology and risk factors. In: Halbe HW. Gynecology Treaty. 4th ed. São Paulo: Roca; 2014. p. 2019.

PINTO, N.T.; OLIVEIRA, T.S. Epidemiological aspects of patients with breast cancer treated at Hospital Ofir Loyola, from 1998 to 2000. (Course Conclusion Paper). Belém (PA): Pará State University - Center for Biological and Health Sciences, 2003.

RIBEIRO, M.A. Effects of unpleasant symptoms of chemotherapy-induced peripheral neuropathy in patients with breast cancer. Dissertation (Master in Nursing) - Postgraduate Program in Nursing, State University of Pará / Federal University of Amazonas, Belém. 2018.

SCHOEMAKER, M.J. et al. Association of Body Mass Index and Age with Subsequent Breast Cancer Risk in Premenopausal Women. JAMA Oncology, 2018. Available in: Accessed on: 25 jun. 2018.

SOUSA, E.D.P.; FILHO, A.B.S., DIAS, C.P. Breast sarcoma: case report. Rev. Bras. of Mastology. 2011; 21 (2): 78-80.

SOUSA, E.D.P.; FILHO, A.B.S.; DIAS, C.P. Estimate 2018: incidence of cancer in Brazil. Rio de Janeiro, 2018. Available at: Accessed on: 23 jun. 2018.




How to Cite

Pacheco de Sousa, E. D., da Silva Souza, G. ., da Mata, N. D. S. ., da Silva, M. P. ., & Secco, J. M. . (2021). WOMEN WITH BREAST CANCER ATTENDED IN PUBLIC HOSPITAL FROM MACAPÁ, AMAPÁ: RISK FACTORS. International Journal for Innovation Education and Research, 9(7), 35–47. https://doi.org/10.31686/ijier.vol9.iss7.3213