Nanocapsules With Naringin And Naringenin Affect Hepatic and Renal Energy Metabolism Without Altering Serum Markers of Toxicity in Rats

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Jadriane Fontoura Friedrich
Jessica Tadiello dos Santos
Ariane Ribas Pohl
Vivian Shinobu Kishimoto Nishihira
Morgana Brondani
Jessica Dotto de Lara
Itiane Diehl de Franceschi
Luciane Rosa Feksa
Renata Platcheck Raffin
Rodrigo de Almeida Vaucher
Virginia Cielo Rech


Naringin and naringenin are flavonoids found in citrus fruits and have several health benefits, however these compounds are susceptible to degradation, limiting their therapeutic application. To solve this problem, an alternative is to incorporate them into nanocapsules. The aim of this work was to evaluate the toxicity of these nanocapsules against renal and hepatic serum markers and also on the activities of pyruvate kinase, Mg2+-ATPase, and creatine kinase. Nanocapsules containing naringin and naringenin, nanocapsules without the active compounds and the compounds in their free form were administered orally, once a day, for 28 days. After treatment, the serum levels of hepatic and renal markers were not altered, nor the activities of pyruvate kinase tissue, however, the treatment of nanocapsules with flavonoids increased the activities of mitochondrial creatine kinase in the kidney and hepatic Mg2+-ATPase. Thus, renal and hepatic serum markers, which are normally used as indicators of toxicity, did not change after the period of administration of the nanoparticles. However, the activities of important enzymes of the energy metabolism in these organs were affected. Our findings reinforce that nanomaterial testing for toxicity needs to go beyond traditional methods to ensure the safe use of nanoparticles for therapeutic purposes.


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Fontoura Friedrich, J., Tadiello dos Santos, J., Ribas Pohl, A., Shinobu Kishimoto Nishihira, V. ., Brondani, M. ., Dotto de Lara, J. ., Diehl de Franceschi, I., Rosa Feksa, L., Platcheck Raffin, R. ., de Almeida Vaucher, R. ., & Cielo Rech, V. (2020). Nanocapsules With Naringin And Naringenin Affect Hepatic and Renal Energy Metabolism Without Altering Serum Markers of Toxicity in Rats. International Journal for Innovation Education and Research, 8(10), 250-262.


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