The Use of Vitamin D in The Infectious Process in The Hospital Period in Childhood Effective?

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Eliza Miranda Ramos
Matheus Dullius de Lima
Jéssica Eloy Cunha Gonzalez
Gilberto Gonçalves Facco
Elaine S. de P. Melo
Hugo Vieira Ramos
Francisco José Mendes dos Reis
Igor Domingos de Souza
Valter Aragão do Nascimento


Goals: To verify whether the use of Vitamin D as parallel therapy to hospital and drug treatment can be effective in the process of infectious reduction in hospitalized children. Data source: This study is a systematic review and meta-analysis of randomized controlled trials, published between 2011 and the first quarter of 2019, in the Cochrane Library, Medline, US National Library of Medicine and the National Institute of Health (PubMed), Literature databases. Latin American and Caribbean Health Sciences (Lilacs), Scopus and Web of Science. The studies were scored by the Down and Black scale associated with the quality assessment method according to the Cochrane criteria (RCT). Summary of the data: Of the 1475 studies, 09 were included. There is a direct relationship between Vitamin D level and mortality rate in hospitalized children with infections. Conclusion: This study highlighted that the vitamin D deficiency in children under serum analysis during hospitalization triggers severe immunological changes.


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How to Cite
Ramos, E. M. ., Lima, M. D. de ., Gonzalez, J. E. C. ., Facco, G. G. ., Melo, E. S. de P. ., Ramos, H. V. ., Reis, F. J. M. dos ., Souza, I. D. de ., & Nascimento, V. A. do . (2020). The Use of Vitamin D in The Infectious Process in The Hospital Period in Childhood Effective?. International Journal for Innovation Education and Research, 8(5), 364-377.
Author Biography

Eliza Miranda Ramos, University of Matogrosso do Sul, Campo Grande, MS, Brazil

Post-Graduate Program in Health and Development in the Midwest Region


ADORINI L, PENNAG. Control of autoimmune diseases by the vitamin D endocrine system. Nature Clinical Practice Rheumatology. v. 4. p.404-412. 2008.

ALVESFS, FREITAS FG, BAFI AT,AZEVEDO LC, MACHADO, FR. Concentração sérica de vitamina D e disfunção orgânica em pacientes com sepse grave e choque séptico. Revista brasileira de terapia intensiva. v.27. n.04. p.376-382. 2015.

BUISON AM, KAWCHAK DA, SCHALL J, OHENE-FREMPONG K, STALLINGS VA, ZEMEL BS. Low vitamin D status in children with sickle cell disease. J Pediatr. v.145. p.622-627.2004.

BUCHOWSKI MS, TOWNSEND DW, WILLIAMS R, CHEN KY. Patterns and energy expenditure of free-living physical activity in adolescents with sickle cell anemia. J Pediatr. v.140. p.92. 2002.

BERWICK M, KESLER D. Ultraviolet radiation exposure, vitamin D, and cancer. Photochemistry and Photobiology, v.81.n.6. p.1261-6. 2005.

HOLICK MF. Vitamin D deficiency. The New England Journal of Medicine. v.357. n.3. p.266-81. 2007.

CARNEIRO J, MURAD Y. Crescimento e Desenvolvimento. In: Agência Nacional de Vigilância Sanitária, editor. Manual de diagnóstico e tratamento de doenças falciformes. Brasília: ANVISA; 2002. p. 77-82.

DE SOUZA KC, DAMIÃO JJ, SIQUEIRA KS, DOS SANTOS LC, DOS SANTOS MR. Nutritional follow-up of children with sickle cell anemia treated in a primary care unit. Rev Paul Pediatr. 2008; 26: 400-4.

DE-LA-TORRE-UGARTE-GUANILO MC.; TAKAHASHI RF.; BERTOLOZZI M. R. Revisão sistemática: noções gerais. Revista da Escola de Enfermagem USP. v. 45, n. 5, p. 1260 - 1266, out. 2011.

MOHER D, LIBERATI A, TETZLAFF J, ALTMAN DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement - PRISMA Group. PLoS Med. v.6. n.7. p.e1000097. 2009.

ZIPITIS CS, AKOBENG, AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Archives of Disease Childhood. v.93. p.512-517. 2008.

PONSONBY AL, PEZIC A, ELLIS J, MORLEY R, CAMERON F, CARLIN J, DWYER T. Variation in associations between allelic variants of the vitamin D receptor gene and onset of type 1 diabetes mellitus by ambient winter ultraviolet radiation levels: a meta-regression analysis. American Journal of Epidemiology. v.168. p.358-365. 2008.

SANTOS CMC, PIMENTA CAM, NOBRE MRCN. A estratégia PICO para a construção da pergunta de pesquisa e busca de evidências. Revista latino americana de enfermagem. v.15. n.3. 2007.

VELDMAN CM, CANTORNA MT, DELUCAHF. Expressão do receptor 1,25-dihidroxivitamina d (3) no sistema imune. Arco. Biochem. Biofísica. v.374 , p.334-338. 2000.

ZMUDA JM, CAULEY JA, FERRELL RE. Molecular epidemiology of vitamin D receptor variants. Epidemiol Rev. v.22, p.203–17. 2000.

ROLF L, MURIS AH, THEUNISSEN R, HUPPERTS R, DAMOISEAUX J, SMOLDERS J. Vitamin D3 supplementation and IL-02/IL-2R pathway in multiple sclerosis: attenuation of progressive disturbances? Journal of Neuroimmunology. v.314. p.50-57. 2018.

KRIEGEL MA, MANSON JE, COSTENBADER KH. Does vitamin D affectrisk of developing autoimmune disease? a systematic review.Semin Arthritis Rheum. v.40, p.512-31, e8. 2011.

SEARING DA, ZHANG Y, MURPHY JR, HAUK PJ, GOLEVA E, LEUNG DY. Decreased serum vitamin D levels in children with asthma areassociated with increased corticosteroid use. J Allergy ClinImmunol. v.125, p.995-1000. 2010.

MISRA M, PACAUD D, PETRYK A, COLLETT-SOLBERG PF, KAPPY M. Drugand Therapeutics Committee of the Lawson Wilkins PediatricEndocrine Society Vitamin D deficiency in children and its management:review of current knowledge and recommendations.Pediatrics. v.122, p.398-417. 2008.

ZAGO MA, PINTO AC. The pathophysiology of sickle cell disease: from the genetic mutation to ultiorgan disfunction. Rev Bras HematolHemoter. v.29, p.2007-14. 2007.

FIXLER J, STYLES L. Sickle cell disease. PediatrClin N Am. v.49, p.1193-210. 2002.

MITCHELL MJ, KAWCHAK DA, STARK LJ, ZEMEL BS, OHENE-FREMPONG K, STALLINGS VA. Brief report: parent perspectives of nutritional status and mealtime behaviors in children with sickle cell disease. J Pediatr Psychol. v.29. p.315-20. 2004.

KAWCHAK DA, SCHALL JI, ZEMEL BS, OHENE-FREMPONG K, STALLINGS VA. Adequacy of dietary intake declines with age in children with sickle cell disease. J Am Diet Assoc. v.107, p.843-8. 2007.

ROVNER AJ, STALLINGS VA, KAWCHAK DA, SCHALL JI, OHENE-FREMPONG K, ZEMEL BS. High risk of vitamin D deficiency in children with sickle cell disease. J Am Diet Assoc. v.108, p.1512-6. 2008.

LEE P, EISMAN JA, CENTER JR. Vitamin D deficiency in critically ill patients. The New England Journal of Medicine. v.360. n.18. p.1912-4. 2009.

SOLIMAN HM, MERCAN D, LOBO SS, MÉLOT C, VINCENT JL. Development of ionized hypomagnesemia is associated with higher mortality rates. Critical Care Medicine. v.31. n.4. p.1082-7. 2003.

ROSS AC, MANSON JE, ABRAMS, SA, ALOIA JF, BRANNON PM, CLINTON SK, RAMON A, DURAZO-ARVIZUJ, CHRISTOPHER GR,RICHARD LG, GLENVILLE J, CHISTOPHER, SK, SUSAN TM, CLIFFORD JR, SUE AS. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The Journal of Clinical Endocrinology & Metabolism. v.96. n.1. p.53-8. 2011.

NIERMAN DM, MECHANICK JI. Bone hyperresorption is prevalent in chronically critically ill patients. Chest. v.114. n.4. p.1122-8. 1998.

VANDEN BG, VAN RD, VANHOVE P, WOUTERS PJ, DE POURCQ L, BOUILLON R. Bone turnover in prolonged critical illness: effect of vitamin D. The Journal Clinical Endocrinology & Metabolism. v.88. n.10. p.4623-32. 2003.

VENKATRAM S, CHLIMURI S, MUHAMMAD A, SALAKO A, MADANMOHAN P, DIAZ-FUENTES G. Vitamin D deficiency is associated with mortality in the medical intensive care unit. Crtical care. v.15. n. R292. p.07-09. 2011.

SARA H D, BLACK, N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. Journal of Epidemiology & Community Health. v.52. p.377–384. 1998.

GALLI, LRR, CARELLO PG, GIAMPIETRO P, PANEI PM. Serum Vitamin D levels and Vitamin D supplementation do not correlate with the severity of chronic eczema in children. Eur Ann Allergy ClinImmunol. Vol47, N2, 41-47, 2015.

REY C, DAVID SA, JESÚS LH, PABLO MC,IRENE GH, BELÉN P, ZAMIR P.Vitamin D deficiency at pediatric intensive care admission. J Pediatria. v.90, n.2, p.135−142. 2014.

DUYGUOH,DEMET A, BULENT H, FERHAT C,GOKHAN A, MUSTAFA K, TUBA M, SELAMI S, FERHAN K. The Association between Serum 25-Hydroxy Vitamin D Level and Urine Cathelicidin in Children with a Urinary Tract Infection. Clin Res PediatrEndocrinol. v.8, n.3, p.325-329. 2016.

JOANNA J, WŁODZIMIERZ S, BŁAŻEJ R, PAWEŁ M, DANIELA P, KATARZYNA WK, IWONA S. Clinical and immunological effects of vitamin Dsupplementation during the pollen season in children with allergic rhinitis. Arch Med Sci 1. January. 2018.

PIYUSH G, POOJA D, DHEERAJ S, NISHA S, NIDHI B, IQBAL RK, AJAY KB, SV M. Vitamin D Supplementation for Treatment and Prevention of Pneumonia in Under-five Children: A Randomized Double-blind Placebo Controlled Trial. INDIAN PEDIATRICS. v.53, 2016.

SPENTA KMBBS, ETIENNE BS, MB CHB, DEREK S, ESTHER A, STANLEY ER, ARI BMD. Vitamin D Supplementation and CD4 Count in Children Infected with Human Immunodeficiency Virus. THE JOURNAL OF PEDIATRICS. Vol. 159, No. 6. December 2011.

SARA HD, BLACK N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health.v.52. p.377–384. 1998.

RAÚL BBA, IVÁN RN, RUBÉN PZ, GONZALO SG. Déficit de vitamina D enni˜nosingresadosen cuidados intensivos pediátricos. Rev ChilPediatr. v.87, n.6, p.480-486. 2016.

DEVI D, SURESH K, NARESH S, RAKESH K, MEENU S, SUNIT S. Fall in Vitamin D Levels during Hospitalization in Children. International Journal of Pediatrics. Article, 6 pages. 2014.

JIAN Z, JUAN D, LETING H, YOUCHENG W, YIMEI S, HAILONG L. Preventive Effects of Vitamin D on Seasonal Influenza A in Infants: A Multicenter, Randomized, Open, Controlled Clinical Trial. The Pediatric Infectious Disease Journal. v.37. n.8. 2018.