Basal cell carcinoma - epidemiology, pathogenesis, pathology, and association with inflammation biomarkers. A review




basal cell carcinoma, epidemiology, pathology, biomarkers, inflammation


Basal cell carcinoma is the most common malignant neoplasm in humans, with low mortality, high morbidity, and exposure to solar radiation (UVB and UVA) is the most critical risk factor. Ultraviolet B rays generate mutagenic photoproducts in DNA and mutations in important genes regulating cellular functions, such as the tumor suppressor gene TP53. Ultraviolet A rays generate cytotoxic and mutagenic free radicals, potentiating the effects of UVB rays.. There is current evidence to support the role of inflammatory biomarkers related to tumorigenesis of basal cell carcinoma.


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DOI: 10.31686/ijier.vol8.iss3.2226

How to Cite

Ramalho, R., Takita, L. C., Sobrinho, C. A., Arakaki Asato, M., Lessa Sacht, G., Hans Filho, G., Tosta Ramalho, R., & Dutrra Aydos, R. (2020). Basal cell carcinoma - epidemiology, pathogenesis, pathology, and association with inflammation biomarkers. A review. International Journal for Innovation Education and Research, 8(3), 246–263.
Received 2020-02-10
Published 2020-03-01

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