Basal cell carcinoma - epidemiology, pathogenesis, pathology, and association with inflammation biomarkers. A review

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https://doi.org/10.31686/ijier.vol8.iss3.2226

Keywords:

basal cell carcinoma, epidemiology, pathology, biomarkers, inflammation

Abstract

Basal cell carcinoma is the most common malignant neoplasm in humans, with low mortality, high morbidity, and exposure to solar radiation (UVB and UVA) is the most critical risk factor. Ultraviolet B rays generate mutagenic photoproducts in DNA and mutations in important genes regulating cellular functions, such as the tumor suppressor gene TP53. Ultraviolet A rays generate cytotoxic and mutagenic free radicals, potentiating the effects of UVB rays.. There is current evidence to support the role of inflammatory biomarkers related to tumorigenesis of basal cell carcinoma.

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[1]. Kim DP, Kus KJB, Ruiz E. Basal Cell Carcinoma Review.Hematol Oncol Clin N Am 33. 2019, 13-24. doi: 10.1016/j.hoc.2018.09.004.
[2]. Instituto Nacional de Câncer “José Alencar Gomes da Silva” (BR). Ministério da Saúde. Estimativa Incidência de Câncer no Brasil. Rio de Janeiro: INCA; 2018. doi: 10.32635/2176-9745.RBC.2018v64n1.115
[3]. Elder David E. et al. WHO Classification of Skin Tumors; 4th Edition; Lyon 2018: 26-34.
[4]. Lupi O, Ribeiro RC, Hoff PM. Câncer Cutâneo. 1. Ed. Rio de Janeiro: Atheneu, 2019.
[5]. Montagna E, Lopes OS. Bases moleculares do carcinoma basocelular. Anais Brasileiros de Dermatologia. 2017; 92(4):518-21. http://www.anaisdedermatologia.org.br/detalhe-artigo/102786/Bases-moleculares-do-carcinoma-basocelular-
[6]. Vasef AM, Auerbach A, et al. Diagnostic Pathology Molecular Oncology. 2th Edition; Philadelfia, PA: Elsevier; 2020:776-779.
[7]. Ribeiro PL, Filho JBS, Abreu KD, Brezinscki MS, Pignation CC. Você conhece esta síndrome? Sindrome de Gorlin-Goltz. Anais Brasileiros de Dermatologia. 2016; 91 (4): 541-3. http://www.anaisdedermatologia.org.br/detalhe-artigo/102521/Voce-conhece-essa-sindrome--
[8]. Marzuka, AG, Book, SE. Basal Cell carcinoma: Pathogenesis, Epidemiology, Clinical Features, Diagnosis, Histopatology and Management. Yale Journal of Biology and Medicine. 88 (2015), p. 167-179. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445438/
[9]. Tang JY, Azterbaum M. Athar M, Barsanti F, Cappola C, Estevez N, Hebert J, Hwang J, Kim A, Lu Y, So PL, Tang X, Kohn MA McCulloch CE, Kopelovich L, Bickers DR, Epstein Jr EH. Basal Cell Carcinoma Chemoprevention with Nonsteroidal Anti-inflamatory drugs in Genetically Predisposed PTCH1+/- Humans. Cancer Prev Res (Phila). 2010; 3(1): 25-34. DOI: 10.1158/1940-6207.CAPR-09-0200
[10]. Tilley C, Deep G, Agarwal R. Chemopreventive Opportunities to Control Basal Cell Carcinoma: Current Perspectives. Molecular Carcinogenesis. 54; 688-697, 2015. doi: 10.1002/mc.22348. Epub 2015 Jun 5
[11]. Busam KJ. Dermatopatologia. 2ª Edição; Rio de Janeiro: Elsevier, 2018:397-406.
[12]. Cameron MC, Lee E, Hibler BP, Baker CA, Mori S, Cordoval M, Nehal KS, Rossi AM. Basal Cell Carcinoma: epidemiology, pathophysiology; clinical and histological subtypes; and disease associations. Journal of the American Academy of Dermatology, Volume 80, Issue 2, February 2019, Pages A38. doi: 10.1016/j.jaad.2018.03.060. Epub 2018 May 18
[13]. Takita LC, Sacht GL. Carcinoma Basocelular. In: Takita LC, Sangueza MA. Patologia de Tumores Cutâneos. Abordagem prática com correlações clínicas. São Paulo: Livraria Livromed Paulista; 2020.
[14]. Pele – Carcinoma Basocelular – (5ª Edição – 2019). SBP, 2019. Disponível em: <http://www.sbp.org.br/mdlhisto/pele-carcinoma-basocelular/>. Acesso em: 30/09/2019.
[15]. Chinem, VP, Miot, HA. Epidemiologia do carcinoma Basocelular. Anais Brasileiros de Dermatologia. 2011;86(2):292-305. doi: 10.1590/S0365-05962011000200013
[16]. Nasser, N. Epidemiologia dos carcinomas basocelulares em Blumenau, SC, Brasil, de 1980 a 1999. Anais Brasileiros de Dermatologia. 2005;80:363-8. http://www.scielo.br/pdf/abd/v80n4/v80n4a06.pdf
[17]. Hoang MP. Immunohistochemistry in Diagnostic Dermatopathology. 1th Edition. New York, NY: Cambridge University Press; 2017.
[18]. Ishi LA, Pereira IC, Schellini SA, Marques MEA, Padovani CR. Carcinoma Basocelular de pálpebra – fatores relacionados com a recidiva. Anais Brasileiros de Dermatologia 2004, 79(4): 423-430. doi: 10.1590/S0365-05962004000400004
[19]. Crowson AN. Basal Cell carcinoma: biology, morphology and clinical implications. Modern Pathology, 2006, 19, S127- S147. doi: 10.1038/modpathol.3800512
[20]. Takita LC, Gdla V, Loro LS, Sanabria BD, Freitas CAF, Abreu AC, Sobrinho CA, Ramalho RT. Basal cell carcinoma in the labial filter: surgical treatment and reconstruction with bilateral perialar advancement flap in ascending. International Journal for Innovation Education and Research. 2019; 7(8): 402-406. doi: 10.31686/ijier.Vol7.Iss8.1701
[21]. Sunjaya AP, Sunjaya AF, Tan ST. The use of BEREP4 immunohistochemistry staining for detection of basal cell carcinoma. Journal of Skin cancer. 2017, 1-10. doi: 10.1155/2017/2692604
[22]. Ramezani M, Mohamadzaheri E, Khazaei S, Najafi F, Vaisi-Raygani A, Rhbar M, Sadeghi M. Comparison of EMA, CEA, CD10 and Bcl-2 Biomarkers by Immunohistochemistry in Squamous Cell Carcinoma and basal cell carcinoma of the skin. Asian Pac J Cancer Prev, 2016, 17 (3), 1379-1383. doi: 10.7314/apjcp.2016.17.3.1379
[23]. Mantese, SAO, Berbert, ALCV, Gomides, MDA, Rocha, A. Carcinoma Basocelular – Análise de 300 casos observados em Uberlândia – MG. Anais Brasileiros de Dermatologia. 2006;81:136-42. doi: 10.1590/S0365-05962006000200004
[24]. Bernard, P, Dupuy, A, Sasco, A, Brun, P, Duru, , Nicoloyannis, N, et al. Basal cell carcinomas and actinic keratoses seen in dermatological practice in France: a cross-sectional survey. Dermatology. 2008;216:194-9. doi: 10.1159/000112925
[25]. Sousa, R.B.; Cunha, F.Q. Inflamação e Câncer. In: HOFF, P.M.G., Editor. Tratado de Oncologia. São Paulo: Atheneu; 2013: v.1. cap.32, p. 431-446.
[26]. St.Clair, JM, Bar-Sagi, D. The role of inflammation in cancer. In: LaFond, RE,Editor. Cancer: the outlaw cell. New York: Oxford University Press; 2012: cap. 12, p: 151-164.
[27]. Rizzo, MBS, Lepique, AP. Inflamação e Câncer. In: Saito, RF., et al. Ed. Fundamentos de oncologia molecular. São Paulo: Atheneu; 2015. Cap. 15, p: 281-299.
[28]. Fernandes JV, Cobucci RNO, Jatoba CAN, Fernandes TAAM, Azevedo JWV, Araujo JMG. The role of the mediators of inflammation in cancer development. Pathol. Oncol. Res. 2015, 21(3): 527-534. doi: 10.1007/s12253-015-9913-z
[29]. Jia J, Shi Y, Yan B, Xiao D, Lai W, Pan Y, Jiang Y, Chen L, Mao C, Zhou J, Xi S, Ya Cao, Liu S, Tao Yy. LGR5 expression is controlled by IKKa in basal cell carcinoma through activating STAT3 signaling pathway. Oncotarget, 2016, 7(19):27 280 – 27294. DOI: 10.18632/oncotarget.8465
[30]. Ciurea ME, Cernae D, Georescu CC, Cotoi OS, Patrascu V, Parvanescu H, Popa D, Parvanescu V, Ciurea RN, Mercut R. Expression of CXCR4, MMP-13 and β-catenin in different histological subtypes of facial basal cell carcinoma. Rom J Morphol Embryol 2013, 54(4): 939-951. http://www.rjme.ro/RJME/resources/files/540413939951.pdf
[31]. Pittayapruek P, Jitlada M, Prapapan O, Komine M, Ohtsuki M. Role of matrix metalloproteinases in Photoaging and Photocarcinogenesis Int. Journal of Molecular Science. 2016, 17, 868. doi: 10.3390/ijms17060868
[32]. Kuznetsova EV, Snarskaya ES, Zavalishina LE, Tkachenko SB. Immunohistochemical study of the specific features of expression. Of matrix metalloproteinases 1, 9 in the photoaged skin, the foci of actinic keratosis and basal cell carcinoma. ArkhPatol. 2016; 78(6): 17-22. DOI: 10.17116/patol201678617-22
[33]. Bridge JA, Lee JC, Daud A, Wells JW and Bluestone JA. Cytokines, chemokines and other biomarkers of response of checkpoint inhibitor therapy in skin cancer. Front. Med. 2018, 5: 351. doi: 10.3389/fmed.2018.00351
[34]. Salan AI, Marasecu PC, Camen A, Cuica EM, Matei M, Florescu AM, Padureanu V, Margaritescu C. The prognostic value of CXCR4, α-SMA ans WASL in upper lip basal cell carcinomas. Rom J MorpholEmbryol, 2018,59(3): 839-849. http://www.rjme.ro/RJME/resources/files/590318839849.pdf
[35]. Sivrikoz ON, Uyar B, Dag F, Tasli F, Sanal SM. CXCR-4 an COX-2 Expression in Basal Cell Carcinomas and well-differentiated Squamous Cell Carcinoma of the Skin; Their relationship with tumor invasiveness and Histological Subtype. Turk Patoloji Derg 2015, 31: 30-35. DOI: 10.5146/tjpath.2014.01279
[36]. Castillo JM, Knol AC, Nguyen JAM, Khammari A, Saint-Jean M, Dreno B. Immunohistochemicalmarkes of advanced basal cell carcinoma: CD56 is associated with a lack of response the vismodegib. Eur J Dermatol, 2016; 26(5): 452-9. https://link.springer.com/article/10.1684/ejd.2016.2826
[37]. Xu CZ, Wang PH, Yan XJ, Wang T, Chen D, Zhang ZJ, Shi RJ. Expression of CXCR4 is associated with progression and invasion in patients with nasal-surface basal cell carcinoma. Journal Otorhinolaryngol Rela Spec. 2013 75(6): 332-41. doi: 10.1159/000357027
[38]. Chen GS, Yu HS, Lan CCE, Chow KC, Lin TY, Kok, lf, Lu MP, Liu CH, Wu MT. CXC chemokine receptor CXCR4 expression enhances tumorigenesis and angiogenesis of basal cell carcinoma. British Journal of Dermatology. 2006 154:910-918. DOI: 10.1111/j.1365-2133.2006.07150.x
[39]. Mantovani, A.; Savino, B.; Locati, M. et al. The chemokine system in cancer biology and therapy. Cytokine Growth Factor Rev, Oxford, 2010, 21(1): 27-39. DOI: 10.1016/j.cytogfr.2009.11.007
[40]. Gozdzialska A, Wojas-Pelc A, Drag J, Brzewski P, Jaskiewicz J, Pastuszczak M. Expression of metalloproteinases (MMP-2 and MMP-9) in basal cell carcinoma. MolBiol Rep 2016, 43:1027-1033. doi: 10.1007/s11033-016-4040-9
[41]. El-Khalawany MA, Abou-Bakr AA. Role of Cylooxyenase-2, Ezrin and Matrix metalloproteinases-9 as predictive markes for recurrence of basal cell carcinoma. Journal of Cancer Research and Therapeutics. 2013 9(4): 613-617. doi: 10.4103/0973-1482.126456
[42]. Ciazynska M, Bednarsli IA, Wodz K, Kolano P, Narbutt J, Sobjanek M, Wozniacka A, Lesiak A. Proteins involved in cutaneous basal cell carcinoma development. Oncology Letters. 2018, 16: 4064-4072. doi: 10.3892/ol.2018.9126
[43]. Ribeiro RIMA, Junior PCB, Cardoso SV, Candelori I, Espindola FS, Cassali D, Loyola AM. Expressão de metaloproteinases de matriz e de seus inibidores teciduais em carcinoma basocelulares. Bras Patol Med Lab, 2008; 44(2): 115-21. Doi: 10.1590/S1676-24442008000200008
[44]. Mohian N, Jewett BS, Baker SR, Varani J. Matrix Metalloproteinase Expressiom in Normal Skin Associated with Basal Cell Carcinoma and in Distal Skin from the Same Patients. Arch Facial Plast Surg. 2005; 7: 238-243. DOI: 10.1001/archfaci.7.4.238
[45]. Zhu L, Kohda F, Nakahara T, Chiba T, Tsuji G, Hachisuka J, Ito T, Tu Y, Moroi Y, Uchi H. Aberrant expression of S100A16 and matrix metalloproteinase 9, but not S100A2, S100A4 and S100A7, is associated with epidermal carcinogenesis. Journal of Dermatological Science 72, 2013: 311-319.
[46]. Karahan N, Baspinar S, Bokurt KK, Ibrahim MC, Kapucuoglu N. Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study. Indian Journal of Pathology Microbiology. 2011 54(3): 526-531. DOI: 10.4103/0377-4929.85086
[47]. Correa MPD, Ferreira AP, Gollner AM, Rodrigues MF, Guerra MCS. Expressão de marcadores de proliferação celular e apoptose em carcinoma basocelular. Anais Brasileiros de Dermatologia 2009, 84(6): 606-614. Doi: 10.1590/S0365-05962009000600006
[48]. Chiacchio ND, Cuce LC. Carcinoma Basocelular: estudo comparativo dos três tipos histológicos mais frequentes em relação à proliferação celular. Anais Brasileiros de Dermatologia. 1997, 72(5): 427-431. https://pesquisa.bvsalud.org/portal/resource/pt/sms-2949
[49]. Lima JSB, Miola AC, Marques MEA, Miot HA. Patterns of proliferation and apoptosis in the diferente subtypes of basal cell carcinoma adjacent epidermis and recurrent forms. An Bras Dermatol. 2019, 94(1): 108-10. Doi: 10.1590/abd1806-4841.20198165
[50]. Maru GB, Gandhi K, Ramchandani A, Kumar G. The role of Inflammation in Skin Cancer. Inflammation and Cancer, Advances in Experimental Medicine and Biology 816, Springer Basel 2014. DOI: 10.1007/978-3-0348-0837-8_17
[51]. Neagu M, Constantin C, Caruntu C, Dumitru C, Surcel M, Zurac S. Inflammation: A key process in skin tumorigenesis (Review). Oncology Letters, 17: 4068-4084, 2019. doi: 10.3892/ol.2018.9735
[52]. Puizina-Ivic N, Sapunar D, Marasovic D, Miric L. An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis. CollAntropol, 2008 oct;32 Suppl 2:61-5. PMID: 19138009
[53]. Aggarwal, B.B.; Vijayalekshmi, R.V.; Sung, B. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res, Philadelphia, 2009, 15(2): 425-430. DOI: 10.1158/1078-0432.CCR-08-0149
[54]. Grivennikov, S.; Greten, F.; Karin, M. Immunity, inflamation, and cancer. Cell, Cambridge, 2010, 140(6): 883-899. doi: 10.1016/j.cell.2010.01.025
[55]. Ghita, MA, Caruntu, C, Rosca, AE, Kaleshi, H, Caruntu, A, Moraru, L, Docea, AO, Zurac, S, Boda, D, Neagu, M, et al: Reflectance confocal microscopy and dermoscopy for in vivo, non-invasive skin imaging of superficial basal cell carcinoma. Oncol Lett. 2016, 11:3019-3024. doi: 10.3892/ol.2016.4354
[56]. Larsimont, JC, Youssef, KK, Sanchez-Danes, A, Sukumaran, V, Defrance, M, Delatte, B, Liagre, M, Baatsen, P, Marine, JC, Lippens, S. et al: Sox9 controls self-renewal of oncogene targeted cells and links tumor initiation and invasion. Cell Stem Cell 17: 60-73, 2015. DOI: 10.1016/j.stem.2015.05.008
[57]. Chastkofsky, MI, Bie, W, Ball-Kell, SM, He, YY, Tyner, AL. Protein tyrosine kinase 6 regulates UVB-induced signaling and tumorigenesis in mouse skin. J Invest Dermatol 135: 2492-2501, 2015. doi: 10.1038/jid.2015.166. Epub 2015 Apr 30
[58]. Baykan, H, Cihan, YB, Ozyurt, K. Roles of white blood cells an subtypes as inflammatory markers in skin cancer. Asian Pac J Cancer Prev. 16: 2303-2306, 2015. DOI: 10.7314/apjcp.2015.16.6.2303
[59]. Lupu, M, Caruntu, A, Caruntu, C, Papagheorghe, LML, Ilie, MA, Voiculescu, V, Boda, D, Constatin, C, Tanase, C, Sifaki, M, et al. Neuroendocrine factors: The missing link in non melanoma skin cancer (Review). Oncol Rep. 38: 1327-1340, 2017. doi: 10.3892/or.2017.5817
[60]. Lin, Y, Chahal, hs, Wu, W, Cho, HG, Ransohoff, KJ, Dai, H, Tang, JY, Sarin, KY, Han, J. Association between genetic variation within vitamin D receptor-DNA binding sites and risk of basal cell carcinoma. Int J Cancer. 140: 2085-2091, 2017. DOI: 10.1002/ijc.30634
[61]. Kaukinen A, Siiskonen, H, Plkonen, J, Harvima, IT. Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers. Eur J Dermatol. 27: 590-598, 2017. DOI: 10.1684/ejd.2017.3132
[62]. Weidenbusch, M, Rodler, S, Song, S, Romoli, S, Marschner, JA, et al. Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis an in response to tissue injury. Biosci Rep. 37: BSR20170099, 2017. DOI: 10.1042/BSR20170099
[63]. Rubina KA, Sysoeva VY, Zaorujko EI, Tsokolaeva ZI, Kurdina MI, Parfyonova YV and Tkachuk VA. Increased expression of uPA, uPAR, and PAI-1 in psoriatic skin and in basal cell carcinomas. Arch Dermatol Res 309:433-442, 2017. DOI: 10.1007/s00403-017-1738-z
[64]. Chaudhary SC, Waseem M, Rana M, Xu H, Kopelovich L, Elmets CA and Athar M. Naproxen inhibits UVB-induced basal cell and squamous cell carcinoma development in Ptch+/-/Skh-1 hairless mice. PhotochemPhotobiol, 2017, 93(4):1016-1024. DOI: 10.1111/php.12758
[65]. Papakostas D and Stockfleth E. Topical treatment of basal cell carcinoma with the immune response modifier imiquimod. Future Oncol. 2015, 11:2985-2990. DOI: 10.2217/fon.15.192
[66]. Muranushi C, Olsen CM, Green AC and Pandeya N. Can oral nonsteroidal anti-inflammatory drugs play a role in the prevention of basal cell carcinoma? A systematic review and metaanalysis. J AmAcadDermatol. 2016, 74:108-119. DOI: 10.1016/j.jaad.2015.08.034

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2020-03-01
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DOI: 10.31686/ijier.vol8.iss3.2226

How to Cite

Ramalho, R., Takita, L. C., Sobrinho, C. A., Arakaki Asato, M., Lessa Sacht, G., Hans Filho, G., Tosta Ramalho, R., & Dutrra Aydos, R. (2020). Basal cell carcinoma - epidemiology, pathogenesis, pathology, and association with inflammation biomarkers. A review. International Journal for Innovation Education and Research, 8(3), 246–263. https://doi.org/10.31686/ijier.vol8.iss3.2226
Received 2020-02-10
Published 2020-03-01

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