• Eliza Miranda Ramos University of Matogrosso do Sul, Campo Grande, MS, Brazil
  • Dr. Gilberto Gonçalves Facco Universidade Anhanguera - UNIDERP, Campo Grande, MS, Brazil.
  • Dr. Valter Aragão do Nascimento Federal University of Matogrosso do Sul, Campo Grande, MS





The term demyelination is used to characterize any inflammatory changes that occur in the medullary or cephalic region.  Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and in general, besides being inflammatory [08, 25], demyelinating and with significant neuronal degeneration, it is considered an important cause of permanent disability in young adults [02-05]. The inflammatory process occurs by an irregular immune response usually mediated by T cells and acts as autoantigens and leads to destruction of the myelin sheath with genetic predispositions [21]. Thus, these chronic and disabling characteristics place a high cost on public health coffers by temporarily or permanently restricting the economic and social activities of their holders and also impacting the lives of their families in a financial and emotional way [15-18]. Still regarding the high cost treatment to inflammatory-infectious processes, primary and autoimmune demyelinating agents, such as sepsis in the adult and child population is considered a critical disease as the main cause of death in children intensive care in Brazil. In recent years in Brazil [24], the high rate of death from sepsis in Brazilian intensive care units has surpassed deaths from stroke and infarction and approximately 230.000 adult patients undergoing intensive care unit treatment have sepsis and estimated 55.7% of hospitalized patients with sepsis died [24]. It is recognized that Vitamin D deficiency is common in both children and adults hospitalized in severe clinical conditions in intensive care [06-12].


Download data is not yet available.

Author Biographies

Dr. Gilberto Gonçalves Facco, Universidade Anhanguera - UNIDERP, Campo Grande, MS, Brazil.

Departamento de Medicina Veterinária

Dr. Valter Aragão do Nascimento, Federal University of Matogrosso do Sul, Campo Grande, MS

Laboratory of Mineral Metabolism and Biomaterials, Dr. Hélio Mandetta Medical School, 


ABDELFATAH M. et al., 2018. Low Vitamin D Level and Impact on Severity and Recurrence of Clostridium difficile Infections. BMJ Journals. v. 63. n. 1. p.17-21. 2015.

ATEF, S.H, 2018. Vitamin D assays in clinical laboratory: Past, present and future challenges. J Steroid Biochem Mol Biol. v.175. p.136-137.

BANWELL B., BAR-OR A., ARNOLD DL, SADOVNICK D, NARAYANAN S, MCGOWAN M, 2011. Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study. Lancet Neurol. v. 10. n. 5. p. 436–45. May.

BIKLE DD et al., 2018. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol. v.84. n.10. p.2194-2207.

BJELAKOVIC G, GLUUD LL, NIKOLOVA D, WHITFIELD K, WETTERSLEV J, SIMONETTI RG, BJELAKOVIC M, GLUUD C, 2014. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database of Systematic Reviews. v.7.

CAMERON LK et al., 2017. Vitamin D levels in critically ill patients with acute kidney injury: a protocol for a prospective cohort study (VID-AKI). BMJ Open.

CHEN, Z. et al. Association of Vitamin D Status of Septic Patients in Intensive Care Units With Altered Procalcitonin Levels and Mortality. J Clin Endocrinol Metab. v.100. n.2. p.516–523. 2015.

CHAUDHURI JR, MRIDLULA KR, UMAMAHESH M, BALARAJU B, BANDARU S, 2018. Association of serum 25-hydroxyvitamin D in multiple sclerosis: a study from India. Neurological disorders and stroke international. v.01. Issue 01. Article 1006.

COCCO E, MELONI A, MURRU MR, CORONGIU D, TRANQUILLI S, FADDA E, MURRU R, SCHIRRU L, SECCI MA, COSTA G, ASUNIS I, FENU G, LOREFICE L, CARBONI N, MURA G, OSATELLI MC, MARROSU MG, 2012. Elements responsive to vitamin D in the HLA-DRB1 promoter region in the alleles associated with multiple sclerosis in Sardinia. PloSOne. v.07. n.07. e41678.

DEVI, D.; SURESH, K.; NARESH, S.; RAKESH, K.; MEENU, S.; SUNIT, S. Fall in Vitamin D Levels during Hospitalization in Children. International Journal of Pediatrics. Article. 6 pages. 2014.

DUYGU OH, DEMET A, BULENT H, FERHAT C, GOKHAN A, MUSTAFA K, TUBA M, SELAMI S, FERHAN K, 2016. The Association between Serum 25-Hydroxy Vitamin D Level and Urine Cathelicidin in Children with a Urinary Tract Infection. Clin Res Pediatr Endocrinol. v.8, n.3, p.325-329.

DWYER T, 2008. Variation in associations between allelic variants of the vitamin D receptor gene and onset of type 1 diabetes mellitus by ambient winter ultraviolet radiation levels: a meta-regression analysis. American Journal of Epidemiology. v.168. p.358-365.

DIAZ-FUENTES G, 2011. Vitamin D deficiency is associated with mortality in the medical intensive care unit. Crtical care. v.15. n. R292. p.07-09.

FLYNN L, et al. Effects of vitamin D deficiency in critically ill surgical patients. Critical Care. v. 203. Issue 3. p.379–382. 2012.

GALLI LRR, CARELLO PG, GIAMPIETRO P, PANEI PM, 2015. Serum Vitamin D levels and Vitamin D supplementation do not correlate with the severity of chronic eczema in children. Eur Ann Allergy Clin Immunol. v.47. n.2. p.41-47.

HASHEMI R, MORSHEDI M, JAFARABADI I et al., 2018 Anti-inflammatory effects of dietary Vitamin D3 in patients with multiple sclerosis. Neurology Genetics. 04. 6. 01-08.

HOLICK MF, et al., 2011. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J. Clin Endocrinol Metabl. v. 96, n. 12, p. 1911-1930. Jul.

HAN, JE et al. 2016. High dose vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial. Journal of Clinical & Translational Endocrinology. v. 4: p.59–65.

HOLMOY T, et al., 2017. High dose Vitamin D supplementation does not affect biochemical bone markers in multiple sclerosis – randomized controlled trial. BMC Neurology. v.17. n.67. p.01-06.

JOANNA J, et al., 2018. Clinical and immunological effects of vitamin D supplementation during the pollen season in children with allergic rhinitis. Arch Med Sci. January .

KOUCHAKI E, et al., 2018. High-dose ω-3 Fatty Acid Plus Vitamin D3Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial. The Journal of Nutrition.

LASKY-SU J, et al., 2017. Metabolism alterations in severe critical illness and vitamin D status. Critical Care. v.21. p.193.

QURAISH I, et al., 2015. Effect of cholecalciferol supplementation on vitamin status D and catheter levels in sepsis: a randomized, placebo-controlled study. Medicine Critical Care, v.43. n.9. p.1928–1937.

RAMOS EM, et al., 2019. Analysis of vitamin d effectiveness of short interventions in the prevention and reduction of sepsis in Brazilian intensive care: a systematic review. International Journal of Development Research. v.09. Issue 02. P. 25670-25677. February.

ZITTERMANN A, et al. 2016. Circulating 25-Hydroxyvitamin D and 1,25Dihydroxyvitamin D Concentrations and Postoperative Infections in Cardiac Surgical Patients: The CALCITOP-Study. Journal Plos One. v. 29. 2016.




How to Cite

Ramos, E. M. ., Facco, D. G. G. ., & Nascimento, D. V. A. do . (2020). VITAMIN D, IN THE BEST CLINIC IN AUTOIMMUNE, INFLAMMATORY INFECTIOUS AND DEMELINIZING DISEASES: A CRITICAL ANALYSIS. International Journal for Innovation Education and Research, 8(4), 554–559.

Most read articles by the same author(s)