Antioxidant effect of Physalis angulata fruit on cells exposed to 2,4- dichlorophenoxyacetic acid


  • Roberta Cattaneo Horn University of Cruz Alta, Brazil
  • GABRIELA TASSOTTI GELATTI University of Cruz Alta, Brazil
  • JANA KOEFENDER University of Cruz Alta, Brazil
  • DIEGO PASCOAL GOLLE University of Cruz Alta, Brazil
  • MARIANA SPANEMBERG MAYER University of Cruz Alta, Brazil
  • TIAGO ANTONIO HERINGER University of Cruz Alta, Brazil
  • MAURICIO BATISTELLA PASINI University of Cruz Alta, Brazil
  • ANA CAROLINE TISSIANI University of Cruz Alta, Brazil
  • AIME CUNHA ARRUDA University of Cruz Alta, Brazil
  • LAURA RUBIN University of Cruz Alta, Brazil
  • RAFAELA DA ROSA RECKTENWALD University of Cruz Alta, Brazil
  • PAULO RICARDO MOREIRA University of Cruz Alta, Brazil
  • CAROLINE ALEGRANSI University of Cruz Alta, Brazil



2,4-dichlorophenoxyacetic acid, Oxygen reactive species, Physalis


Several in vitro studies have described the erythrocyte toxicity mechanism response to the 2,4-dichlorophenoxyacetic acid (2,4-D) and its metabolites, strongly related to oxidative stress. Compounds such as ascorbic acid and flavonoids, present in various fructiferous plants like Physalis angulata L.- Solanaceae, are exogenous sources of antioxidants, which have aroused interest because of its beneficial biological effects to health by capturing oxygen reactive species. Here, was investigated the cytotoxic effects of the 2,4-D in human erythrocytes exposed to this herbicide and treated with the juice of P. angulata fruits. Analyzing the oxidant and antioxidant mechanisms in these cells in vitro, was demonstrated that the damage mechanism by the Physalis juice occurred at the level of cellular proteins and membranes, altering levels of endogenous antioxidants components such as reduced glutathione and uric acid, and exogenous like vitamin C. Our results indicate new insights into the mechanism of human erythrocytes response exposed to the P. angulata juice, providing wayforward to future studies of cytotoxicity.


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How to Cite

Horn, R. C., GELATTI, G. T. ., KOEFENDER, J. ., GOLLE, D. P., MAYER, M. S. ., HERINGER, T. A. ., PASINI, M. B. ., TISSIANI, A. C. ., ARRUDA, A. C. ., RUBIN, L. ., RECKTENWALD, R. D. R., MOREIRA, P. R. ., & ALEGRANSI, C. . (2019). Antioxidant effect of Physalis angulata fruit on cells exposed to 2,4- dichlorophenoxyacetic acid. International Journal for Innovation Education and Research, 7(8), 374–386.

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